ThePharmaFacts

The Covid-19 Vaccine Race: Phase I: 1.BEIJING MINHAI BIOTECHNOLOGY (CHINA) INACTIVATED VACCINE A Phase 1 trial of this vaccine started on 2 October, with 180 health people aged over 18 years. The trial is being done in Jiangsu, China. 2.IMMUNITYBIO AND NANTKWEST (USA) VIRAL VECTOR VACCINE The company is planning to launch a Phase 1 trial in California this month with people aged up to 55 years. It is an adenovirus (Ad5) vaccine designed to deliver both spike protein and nucleocapsid DNA to drive both cellular and antibody immunity. Earlier this year, it was chosen to be part of Operation Warp Speed to rapidly develop vaccines in the USA. 3.REITHERA (ITALY) VIRAL VECTOR VACCINE The Italian biotechnology company ReiThera has developed a COVID-19 vaccine, called GRAd-COV2, based on an adenovirus that infects gorillas. In collaboration with the Lazzaro Spallanzani National Institute for Infectious Diseases, they launched a Phase 1 trial at the end of July. 4.CANSINO BIOLOGICS/ACADEMY OF MI...

Vaccine Manufacturing: Clinical Trials           Scientists around the world are continuously working on COVID Pandemic Vaccine Development; out of that, some vaccine markers are very close to accurate results. Around the world, more than 23 million Covid cases are found and 800,000+ deaths globally, Over the World more than 150 labs are constantly working on developing Covid-19 Vaccine. No one other than Russia has declared his vaccine is the safest vaccine over the Covid-19 pandemic. Apart from this vaccine development; the second largest problem to healthcare systems is, how to make this vaccine available to the global population at an affordable cost. Clinical trials: Clinical trial is an investigation of a newly discovered drug on a human subject on a human subject, and reporting its safety and efficacy. It is carried out in the following ways It is carried out in the following ways:     After successfully completing of Preclinical Phase...

               We deal with general ideas about Apoptosis in earlier blog (Apoptosis Phase 1). Now in this blog we are going to deal with two important points which are:   1. Apoptosis Pathways   2. Apoptosis Assays(only name)          1. Apoptosis Pathways                    A] Extrinsic pathway (death receptor-mediated events)                    i. Death receptors and their Ligands :          -death receptors are members of TNF (tumor necrosis factor) receptor super family.          -they have cytoplasmic domain of 80 amino acid which is called Cellular Death Domain (CDD).          -CDD plays vital role in death signal transmission from cell surface to intracellular signalling.            ...

  Nitric oxide a possible treatment for COVID-19.           Covid-19 (Coronavirus disease) is a respiratory tract infection caused by a coronavirus closely related to SARS coronavirus. Generally, Covid-19 patients show hypoxemia associated with acute respiratory distress syndrome (ARDS). Hypoxemia means lowering of oxygen level in the blood, hence we need advanced mechanisms to transfer oxygen from alveoli to blood. Many experimental & clinical evidence explains the significant role of Inhaled Nitric Oxide(NO) as a selective vasodilator. , which has shown to restore oxygenation by helping to normalize shunts and ventilation/perfusion mismatch. NO has ability to suppress the replication of coronavirus, only NO has this unique property than other vasodilator agents. Hence it helps to clinical management of COVID-19 .     Researchers in many universities continuously working on the COVID-19 vaccine, a scientist at Uppsala University have d...

        In December 2019, an epidemic of pneumonia caused by a novel virus later identified as severe acute respiratory syndrome coronavirus 2 (SARS–CoV-2) started in the city of Wuhan, Hubei province, China. Recently, the World Health Organization (WHO) has declared coronavirus disease 2019 (Covid-19) , a pandemic of global health concern. The researchers have been focused on the prevention and treatment of this disease. Nonetheless, while the development of new drugs or vaccines would take a long time before human testing and commercialization, clinical trials on available pharmaceuticals with a potential effect against Covid-19 could more easily yield useful results and, as a matter of fact, are already being performed. Vitamin D is usually known for its role in the maintenance of bone health and calcium-phosphorus metabolism, yet many other roles of this hormone have been recently discovered, such as modulat...

          Normally COVID-19(Coronavirus) targets mainly the respiratory system of the human body, many people suffering from chronic respiratory disease those people get easily targeted by the COVID-19 virus, but if you are pregnant then your problems will be going to increases, prescribing medication for pregnant women been always tough for a gynecologist in term of mother and fetus health is a concern, but now problems are getting more worst by the entry of COVID-19.           If you are pregnant, then your mind has a lot of questions like, will your baby child live safely in this pandemic ? or if you have tested positive for Covid-19 , what will you do? etc The answers have not been found yet, scientists are constantly working on it.           Indian Council of Medical Research-National Institute Research in Reproductive Health (ICMR-NIRRH), in collaboration with the Medical Education and Drug...