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Popular Posts

REMDESIVIR - A BURNING TOPIC

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                Patients all over world are facing tremendous health care hazards that are caused by the Severe Acute Respiratory Distress Syndrome Coronavirus 2 (SARS-CoV-2) pandemic. Remdesivir {First described in 2016} is the first approved treatment for severe coronavirus disease 2019 (COVID-19). It is a " Novel Nucleoside Analog " with a broad antiviral activity spectrum among RNA viruses, including Ebolavirus (EBOV) and Respiratory Pathogens like the Middle East Respiratory Syndrome Coronavirus (MERS-CoV), SARS-CoV, and SARS-CoV-2. In vivo, Remdesivir showed therapeutic as well as prophylactic effects in animal models of EBOV, MERS-CoV, SARS-CoV, and SARS-CoV-2 infection. However, the substance failed to some extent in a clinical trial on ebola virus disease (EVD), where it was inferior to investigational monoclonal antibodies in an interim analysis. As there was no placebo control in this study, no conclusions on its efficacy in EVD can be made. In contrast, data from
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Corona Virus (COVID-19). (Detailed through WHO )

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Overview:                 Nowadays many people infected with the COVID-19 virus.  This virus mainly attacks the Respiratory system. Aged persons and those persons who suffer from other health problems like Asthma, diabetes, other chronic respiratory diseases, cancers, and various immunological diseases, can be easily affected by the COVID-19 virus.           The most ideal approach to prevent and hinder transmission is by taking various awareness programs advertisements, seminars, and explains the severity of the COVID-19 virus. Its causes and how it spread. Shield yourself as well as other people from contamination by washing your hands time by time or by using at least 60% alcohol-containing hand-sanitizers , hands rubs frequently by using these sanitizers and not touching your face.         The main reason for COVID-19 spreading is through salivary droplets or discharge from the nose when a nearby person coughs or sneezes, so it's significant that you likewise practice respirato
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Thyroid Hormones [I]

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  Thyroid Hormones: Analogues & Their Inhibitors    Thyroid gland:    - Location: front of Neck, below the Adam's Apple (larynx).   - butterfly-shaped gland.   - it is composed of Million clusters of follicles.   - a follicle is a structure having epithelial cells surrounding a central mass (colloid).   - Epithelial cells:          (i) follicular cells[T3 & T4]         (ii) parafollicular cells [calcitonin]   - having two lobes; either on the windpipe (trachea).   Thyroid Hormone Actions:    i.Growth & Development   ii.Intermediary metabolism (lipid,carbohydrate & protein metabolism)   iii.Caloriegenesis-production of heat via digestion of food or action of several hormones thus BMR increases   iv.Haemopoiesis   v.Modulate gene transcription   Synthesis, Storage & Release of Thyroid Hormones:     1.Iodine uptake/Trapping:    -total iodine content in body is 30-50 mg out of which ⅕th is present in thyroid    -blood iodine concentration is low i.e. 0.2-0.4 μg/dl  
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CEPHALOSPORIN : ANTIBIOTIC

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Cephalosporins Derived from a fungus Acremonium which word is previously known as Cephalosporium Discovered in 1945 by Brotzu He observed that the culture produced substances which were effective against Salmonella typhi (an agent causing typhoid) General Information:     General Structure:                SAR Of Cephalosporins:      1.  7-Acylamino substituents: -      Acylation of the amino group generally increases potency against gram  positive bacteria, but decrease in gram-negative potency. -     High antibacterial activity is observed only when the new acyl groups are derived from carboxylic acids for gram-positive bacteria. -    Substituents on the aromatic ring that increases lipophilicity provide higher gram-positive activity and generally lower gram-negative activity. -    Phenyl ring in the side-chain can be replaced with other heterocycles with an improved spectrum of activity and pharmacokinetic properties and these include thiophene, tetrazole, furan, p
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Zydus Healthcare launches generic anti-diabetic Dapagliflozin tablets in India.

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       Zydus Healthcare launched its Dapagliflozin in two variants, 10mg and 5mg with   Rs 17 and Rs 14 respectively.    New Delhi: Leading Medicine Manufacturing company Zydus launches Dapagliflozin tablets, across the country with the brand name “Dapaglyn” at a very pocket-friendly cost.                                                   This medicine daily prescribed as an adjuvant to diet and exercise, and the main purpose to control the glycemic level in adults suffering from type 2 diabetes mellitus, Zydus healthcare explained.           Zydus launched this anti-diabetic medicine in two strengths of 10mg and 5mg with price Rs. 17 and Rs 14 respectively, which priced at ⅓ cost than currently available medicine. Due to this reason, this therapy becomes very economical, easily accessible, and very affordable to Patients. How does Dapagliflozin act on the human body?           Dapagliflozin is the newly invented class named by sodium-glucose co-transporter 2 (SGLT2)  inhibitors, t
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