ThePharmaFacts

Cephalosporins Derived from a fungus Acremonium which word is previously known as Cephalosporium Discovered in 1945 by Brotzu He observed that the culture produced substances which were effective against Salmonella typhi (an agent causing typhoid) General Information:     General Structure:                SAR Of Cephalosporins:      1.  7-Acylamino substituents: -      Acylation of the amino group generally increases potency against gram  positive bacteria, but decrease in gram-negative potency. -     High antibacterial activity is observed only when the new acyl groups are derived from carboxylic acids for gram-positive bacteria. -    Substituents on the aromatic ring that increases lipophilicity provide higher gram-positive activity and generally lower gram-negative activity. -    Phenyl ring in the side-chain can be replaced wi...