ThePharmaFacts

     TETRACYCLINE All are obtained from Actinomycetes species  T hey are bitter solids & their hydrochlorides soluble in water Derivatives of Octahedro Napthacene (having 4 annulated six- membered rings together) Amphoteric compounds (having both acid & base properties)   General Information:      General Structure:      SAR of Tetracyclines:       1.Modification at C1 & C3:         -  Keto-enol tautomerism of ring A in C1  &  C3 is common feature to all biologically active tetracyclines, blocking this system by forming derivatives  like A–C = O  at C1 and C3 results in loss of antibacterial activity          - Function of C1 & C3 is essential for activity       2. Modification at C2 position:          - Antibacterial activity depends on the carboxamide (CONH 2 ) moiety.   ...

              Local Anesthetics : (LA)      - These agents prevent generation and conduction of nerve impulses at the site of application or injection    - This leads to loss of sensation which is reversible    - Also causes absence of pain sensation at specific location without loss of consciousness hence also known as "Local Analgesics"         Routes of Administration :     i) Topical Anaesthesia (Surface)    ii) Intravenous (IV) - Either for regional nerve block or for large region block    iii) Spinal Anaesthesia (Within spinal theca)         Mechanism of Action of LA :    i) Generation and propagation of nerve impulses at the site of action on cell membrane are blocked    ii) Blocking of Na/K ATPase enzyme leads to Na & K ions influx & outflux restriction respectively therefore membrane stabilization   ...

               Indian Pharmacopoeia is an official book published by the Ministry of health and family welfare; which includes drug monographs, standard operating procedures & various guidelines from manufacturing to storage. In India, every pharmaceutical industries follow this book as officially.lets come to our headline                 The Indian Pharmacopeia (IP) has been perceived officially by the National Department of Regulation of Medicines and Health Products of the Ministry of Public Health of the Islamic Republic of Afghanistan. Based on their requirement, they will use our reputed pharmacopeia for improvement in the laboratory of medicine and healthcare quality products. With this step, Afghanistan has become the first nation to refer to Indian pharmacopeia as their official choice.          Indian Pharmacopeia is an...